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IPhones Take Over the Internet

2007-12-04T21:47:00.000-05:00

Amazing. Really amazing.

iPhone owners were responsible for nearly one out of every 1,000 Web page views last month. This erases any doubt that the future of mobile devices most certainly includes the Web.

The iPhone has the same browser as Apple’s computers, meaning iPhone owners can see the same version of Web pages people see on their PCs.

IPhone owners embraced the browser to the extent that they represented 0.09% of all Web pages viewed in November. That doesn’t sound like much, but consider that through September, Apple had only sold 1.4 million iPhones.

As a point of comparison, devices running every version of Windows mobile operating system combined made up 0.06% of Web page views.

Companies have been making mobile devices that run Windows since 1996, according to Computer World, and three million of the devices were shipped in the first quarter of 2007 alone, according to research company Gartner.

By our calculations, iPhone owners are about 90 times more likely to view a Web page than the typical Internet user, of whom there are approximately 1.25 billion worldwide.

IPhones Take Over the Internet

Posted by Ben Worthen

We’ve always felt that the iPhone’s game-changing feature was its Web browser. Now we have proof: iPhone owners were responsible for nearly one out of every 1,000 Web page views last month. This erases any doubt that the future of mobile devices most certainly includes the Web.

Many phones have Web browsers, but most of the time these were made specifically for mobile devices and only give phone owners access to watered-down versions of Web sites. The iPhone has the same browser as Apple’s computers, meaning iPhone owners can see the same version of Web pages people see on their PCs.

IPhone owners embraced the browser to the extent that they represented 0.09% of all Web pages viewed in November. That doesn’t sound like much, but consider that through September, Apple had only sold 1.4 million iPhones. As a point of comparison, devices running every version of Windows mobile operating system combined made up 0.06% of Web page views. Companies have been making mobile devices that run Windows since 1996, according to Computer World, and three million of the devices were shipped in the first quarter of 2007 alone, according to research company Gartner. Here’s some more perspective: By our calculations, iPhone owners are about 90 times more likely to view a Web page than the typical Internet user, of whom there are approximately 1.25 billion worldwide.

It’s obvious that people have a need for Web access even when they aren’t at their desks or at home or wherever else they have a PC. We think that businesses could make their employees more productive by making sure that the mobile devices they give them have a full-fledged browser. We’re not saying companies should go out and buy everyone an iPhone – although if you do we’d love to hear about it. But presumably, it’s just a matter of time until an iPhone-like browser is a standard feature on mobile devices.

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The latest in Financial Infotainment--Minyanville

2007-07-19T12:54:00.000-04:00

A friend of mine sent me a link to this website, Minyanville. The site is will worth visiting. Informative and entertaining. The stuff on China, subprime loans and trading is thought provoking. Chances are good you will be sending this link along to your freinds.

Some examples of the headline stories.

Fire in the Hole!
Todd Harrison
...as yesterday’s false alarm once again proved, structural smoke won’t matter until someone actually sees a fire.

Testing the Waters of Intel
Jeff Macke
Plucking at the strings of lunacy, trying to find something valid enough to trade off, thus becomes a somewhat futile exercise...

Stocks To Watch: Dell, eBay, Ford, IBM, Sysco
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Today's top stories and some stocks with potential to move...

Bear Stearns' Hedge Fund Mess
Bennet Sedacca
Brokerage paper has been widening relative to Treasuries of late, but so has everything else, as perhaps it should.

The Market's Remarkable Symmetry
The market may have an agenda higher in terms of time and price, but... there are many clusters of time, price and pattern projecting a turning point in this neighborhood.

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hedge funds, infotainment, investing, minyanville, subprime loans, trading

Myriad Genetics (MYGN) Presents Mathematical Comparison of Disease Modification Trial Designs at Alzheimer's Conference

2007-06-11T23:13:00.000-04:00

Case-Shiller Home Price Index

2007-05-11T11:07:00.000-04:00

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Case-Shiller Home Price Index

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Case-Shiller Home Price Index

According to the S&P/Case-Shiller Home Price Index, home prices in Seattle are up how much from a year ago?

According to the S&P/Case-Shiller Home Price Index, home prices in Seattle are up how much from a year ago?

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2007-05-02T12:40:00.000-04:00

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EF Hutton: According to the latest NBC/WSJ poll, what percentage of Americans believe the nation is headed in the right direction?

2007-04-26T11:12:00.000-04:00

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2007-04-20T10:47:00.000-04:00

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Shareholders of Firstgroup will meet today to close a 1.8B pound takeover deal of what major U.S. services company?

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Robert T DeMarco Weblog: CNBC Portfolio Challenge Bonus Bucks Answers

2007-04-18T11:39:00.000-04:00

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2007-04-09T10:48:00.000-04:00

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2007-04-03T11:51:00.000-04:00

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2007-03-30T12:43:00.000-04:00

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2007-03-29T12:04:00.000-04:00

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2007-03-19T10:13:00.000-04:00

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Robert T DeMarco Weblog: Ethanol inflames grain market

2007-01-15T23:05:00.000-05:00

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The CareGiver: Huperzine A Factsheet (Alzheimer's)

2006-11-18T15:39:00.000-05:00

I recently read about Huperzine A. The following page contains a fact sheet about the herb. Huperzine A may have cognition-enhancing activity in some.

Source Huperzine A

TRADE NAMES

Huperzine A is available from numerous manufacturers generically. Branded products include Memorall (PharmAssure), Huperzine Rx-Brain (Nature's Plus).

DESCRIPTION

Huperzine A is a plant alkaloid derived from the Chinese club moss plant, Huperzia serrata, which is a member of the Lycopodium species. Huperzia serrata has been used in Chinese folk medicine for the treatment of fevers and inflammation.

Huperzine A has been found to have acetylcholinesterase activity. Huperzine B, also derived from Huperzia serrata, is a much less potent acetylcholinesterase inhibitor. Natural huperzine A is a chiral molecule also called L-huperzine A or (-)-huperzine A. Synthetic huperzine A is a racemic mixture called (±)-huperzine A. Huperzine A is also known as HUP, hup A and selagine. In Chinese medicine, the extract of Huperzia serrata is known as Chien Tseng Ta and shuangyiping. Huperzine A derivatives are being developed for pharmaceutical application.

ACTIONS AND PHARMACOLOGY ACTIONS

Huperzine A may have cognition-enhancing activity in some.

MECHANISM OF ACTION

Alzheimer's disease is a neurodegenerative disorder associated with neuritic plaques that affect the cerebral cortex, amygdala and hippocampus. There is also neurotransmission damage in the brain. One of the major functional deficits in Alzheimer's disease is a hypofunction of cholinergic neurons. This leads to the cholinergic hypothesis of Alzheimer's disease and the rationale for strategies to increase acetylcholine in the brains of Alzheimer's disease patients. Two FDA-approved drugs for the treatment of Alzheimer's disease, tacrine and donepezil, are acetylcholinesterase inhibitors.

Huperzine A is also an acetylcholinesterase inhibitor and has been found to increase acetylcholine levels in the rat brain following its administration. It also increases norepinephrine and dopamine, but not serotonin levels. The natural L or (-)-huperzine A is approximately three times more potent than the racemic or (±)-huperzine A in vitro.

PHARMACOKINETICS

There are limited pharmacokinetic studies with huperzine A. It appears that huperzine A is rapidly absorbed from the gastrointestinal tract and transported to the liver via the portal circulation. Some first-pass metabolism takes place in the liver, and huperzine A and its metabolites are distributed widely in the body, including to the brain. Following ingestion, the time to reach peak blood level is approximately 80 minutes.

INDICATIONS AND USAGE

Huperzine A has potent pharmacological effects and, particularly since long-term safety has not been determined, it should only be used with medical supervision. It may have some effectiveness in Alzheimer's disease and age-related memory impairment. It has been used to treat fever and some inflammatory disorders, but there is no credible scientific evidence to support these uses.

RESEARCH SUMMARY

Numerous studies, most of them from China, suggest that huperzine A may be as effective as the drugs tacrine and donepezil in Alzheimer's disease. This is not so surprising since in vitro and animal model tests have demonstrated that huperzine A effectively inhibits acetylcholinesterase, an enzyme that catalyzes acetylcholine breakdown. Tacrine and donepezil work in the same way to conserve acetylcholine in the brain--the mode by which they presumptively improve memory and cognition in those with Alzheimer's and age-related cognitive impairment. Huperzine A may prove superior to tacrine (dose-limited due to its hepatotoxicity) if long-range studies, yet to be conducted, demonstrate its safety.

In one double-blind, randomized study, huperzine A, in injectable form, was tested against a saline control in 56 patients with multi-infarct dementia or senile dementia and in 104 patients with senile and pre-senile simple memory disorders. Huperzine A produced significant positive effects as measured by the Wechsler Memory Scale. Dizziness was experienced by a few of the huperzine A-treated patients.

In another study, this one multicenter, double-blind, placebo-controlled and randomized, 50 subjects with Alzheimer's disease were given huperzine A or placebo for eight weeks. Significant improvement was noted in 58 percent of the patients in terms of memory, cognitive and behavioral functions. Research is ongoing.

CONTRAINDICATIONS, PRECAUTIONS, ADVERSE REACTIONS CONTRAINDICATIONS

None known.

PRECAUTIONS

Huperzine A should be avoided by children, pregnant women and nursing mothers.

Because of possible adverse effects in those with seizure disorders, cardiac arrhythmias and asthma, those with these disorders should avoid huperzine A. Those with irritable bowel disease, inflammatory bowel disease and malabsorption syndromes should avoid huperzine A.

ADVERSE REACTIONS

Adverse effects reported with huperzine A include gastrointestinal effects, such as nausea and diarrhea, sweating, blurred vision, fasciculations and dizziness. Possible adverse effects include vomiting, cramping, bronchospasm, bradycardia, arrhythmias, seizures, urinary incontinence, increased urination and hypersalivation.

INTERACTIONS DRUGS

Acetylcholinesterase Inhibitors: Use of huperzine A along with the acetylcholinesterase inhibitors donepezil or tacrine may produce additive effects, including additive adverse effects. Other acetylcholinesterase inhibitors include neostigmine, physostigmine and pyridostigmine, and use of these agents along with huperzine A may produce additive effects, including additive adverse effects.

Cholinergic Drugs: Use of huperzine A along with cholinergic drugs, such as bethanechol, may produce additive effects, including additive adverse effects.

NUTRITIONAL SUPPLEMENTS

Use of huperzine A with choline, phosphatidylcholine, CDP-choline and L-alpha-glycerylphosphorylcholine hypothetically might produce additive effects, including additive adverse effects.

OVERDOSAGE

There are no reports of overdosage with huperzine A.

DOSAGE AND ADMINISTRATION

There are various forms of huperzine A available, including extracts of Huperzia serrata, natural (-)-huperzine A and synthetic racemic (±)-huperzine A. Natural (-)-huperzine A is approximately three times more potent than the synthetic racemic mixture. The doses of natural (-)-huperzine A used in clinical studies ranged from 60 micrograms to 200 micrograms daily. Huperzine A should only be used with a physician's recommendation and monitoring.

HOW SUPPLIED

Capsules — 50 mcg

Tablets — 50 mcg

LITERATURE

Cheng DH, Tang XC. Comparative studies of huperzine A, E-2020 and tacrine on behavior and cholinesterase activities. Pharmacol Biochem Behav. 1998; 60:377-386.

Cheng DH, Ren H, Tang XC. Huperzine A, a novel promising acetylcholinesterase inhibitor. Neuroreport. 1996; 8:97-101.

Quian BC, Wang M, Zhou ZF, et al. Pharmacokinetics of tablet huperzine A in six volunteers. Chung Kuo Yao Li Hsueh Pao. 1995; 16:396-398.

Tang XC, Kindel GH, Kozikowski AP, Hanin I. Comparison of the effects of natural and synthetic huperzine A on rat brain cholinergic function in vitro and in vivo. J Ethnopharmacol. 1994; 44:147-155.

Xiong ZQ, Tang XC. Effect of huperzine A, a novel acetylcholinesterase inhibitor, on radial maze performance in rats. Pharmacol Biochem Behav. 1995; 51:415-419.

Xu SS, Gao ZX, Weng Z, et al. Efficacy of tablet huperzine-A on memory, cognition and behavior in Alzheimer's disease. Chung Kuo Yao Li Hsueh Pao. 1995; 16:391-395.

Ye JW, Cai JX, Wang LM, Tang XC. Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment. J Pharmacol Exp Ther. 1999; 288:814-819.

Zhang RW, Tang XC, Han YY, et al. Drug evaluation of huperzine A in the treatment of senile memory disorders. [Article in Chinese] Chung Kuo Yao Li Hsueh Pao. 1991; 12:250-252.

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The CareGiver: Huperzine A Factsheet (Alzheimer's)

2006-11-18T15:38:00.000-05:00